Ida Arts - A gallery of cartoons about a misfortunate cat named Cas.
Idiom Syndrome - A photo-webcomic with random humour for the most part.
Ignaki - A collection of cartoons about food, computers, art; translated into English. By Ignacio Lafferriere.
I'm Blue - Highlights the trials, tribulations and comedy of the main character Blue Veers, and her friends Celia, Derec, Tyger, Max, and Duo.
The Imp - A humor strip about hell, by Jose Arroyo and Robin Reed.
In Real Life - Following the adventures of Mario, Mega Man, and Link when they are sucked out of the Super NES.
In the Bleachers - Steve Moore's syndicated humor cartoon about sports.
In the Dark - Demons and Angels. Where the battle to free Demonkind from the Netherworld is about to break out. By Alex.
In The Puddle - Semi-reality webcomic by Cique Johnson, about bisexual, lesbian and straight young adults in Philadelphia - starring artist and pastafarian Cique, her guy, and pet bat.
Inepto.com - Lampoons ineptitude at all levels of society, from customer service to CEOs and politicians.
The Infirm - Humor comic about a first-year associate attorney.
Ink On Paper - We've got Magic Pig, Supa Fly, Bob Quackers and more strips.
Inktank.com - Two strips: Angst Technology, about a game development company, and Weak-end Warriors, about paintball.
Innies and Outties - Funny comic strip about two latchkey kids imagining their way through the enchanted land of suburbia. By Leonard Cachola.
Insane Add-a-Panel - Add a panel to this comic. An always changing comic.
Insane Comics - A normal sprite comic site but with a twist. Include Super Heroes In Training, Unit 003, 8 Bit Insanity, and Megaman SC.
Intelligent Humor - Offbeat comic, also known as "Big Meaty Chunks", by Chris Williams. Collected by Steven Dengler of Xenon Labs.
Interns - Features three interns as they work at a prominent comic book publisher. Includes character bios.
Intershadows - Features an archive of the title, a gallery of sketches and illustrations, and the series Coolville. By Kathleen Jacques.